Brazil’s fight against TB yields slow progress



Brazil’s Ministry of Health (MoH) this week published a report on tuberculosis (TB) in the country, showing that incidence dropped slightly from 75,717 new cases in 2018 to 73,864 last year, although this is still higher than the 69,802 cases recorded in 2015. Mortality has shown a more steady reduction, going from 4,881 deaths in 2008 to 4,490 in 2019.

Although the Unified Health System (SUS) covers the treatment for TB, the disease continues to result in deaths due to 10% of patients not adhering to the 6-month-long treatment, which spans an initial phase administering isoniazid, rifampicin, ethambutol, and pyrazinamide, followed by a maintenance phase that uses isoniazid and rifampicin.

Brazil has recently doubled its efforts against TB, including the development by the Oswaldo Cruz Foundation (Fiocruz) of a single TB tablet to reduce pill burden, last year’s announcement to adopt an effervescent tablet against the disease, and the MoH heading the United Nations (UN)’s Stop TB Partnership since last year.

Reference:

Related news
China-based Shanghai Fosun Pharmaceutical (Group) Co., Ltd (SHA:600196; HKG:02196) released its Q4 2019 financial report.
Argentina’s Comprehensive Medical Attention Program (PAMI), the largest healthcare program in the country, today adopted a list of medicines that will be provided to patients free of charge, according to a declaration from President Alberto Fernández.
The South Africa-­based non-profit drug developer TB Alliance entered into a license agreement with China-based Shanghai Fosun Pharmaceutical (Group) Co., Ltd (600196.SH) subsidiary Shenyang Hongqi Pharmaceutical Co., Ltd. The deal is focused on the former's tuberculosis (TB) drug pretomanid, and gives rights to Hongqi to market the triple-combination therapy BPaL, consisting of pretomanid, Johnson & Johnson’s bedaquiline, and Pfizer’s linezolid, as a treatment for extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant tuberculosis (MDR-TB) in China. Fosun Pharma previously obtained exclusive development, manufacturing, and sales rights to TB Alliance’s novel pulmonary tuberculosis therapy PaMZ (pretomanid + moxifloxacin + pyrazinamide) via a deal struck in 2014.
Provincial tendering and health insurance authorities in Henan, Hunan, and Guangxi have all released notifications ordering local hospitals to draw up volume-usage data in preparation for the next round of the volume-based procurement (VBP) program.
Brazil’s Ministry of Health (MoH) this week announced that the National Commission for the Incorporation of Technologies (CONITEC) will evaluate the inclusion of rifapentine into the Unified Health System (SUS) as a treatment to prevent latent tuberculosis (TB) from activating.
Recent news
The National Medical Products Administration (NMPA) last week revealed that Celgene’s Abraxane (paclitaxel, albumin bound) would lose its import clearance after agency inspectors uncovered manufacturing issues at the Fresenius Kabi plant responsible for manufacturing the drug. The news impacts Chinese biotech BeiGene Inc., which generated around USD 100 million with Abraxane in China as the drug's marketing agent under license from Celgene.
  • 1585666816337
  • China
Pfizer subsidiary Wyeth this week obtained a marketing approval from Brazil's National Health Surveillance Agency (ANVISA) for its iron replacement therapy Monofer (ferric derisomaltose), as GBI analysis shows.
Hugo Sigman, founder of of Argentina-based group Insud Pharma, last week commented on Argentina’s biopharmaceutical industry as the COVID-19 pandemic puts the health sector to test.
China-based Shanghai Fosun Pharmaceutical (Group) Co., Ltd (SHA:600196; HKG:02196) released its Q4 2019 financial report.
According to GBI analysis, Mexico’s Federal Commission for the Protection against Health Risks (COFEPRIS) has published recent market approvals for Swiss major Novartis subsidiary Sandoz’s Arasamila (rituximab), Japan-based Daiichi Sankyo’s factor Xa (FXa) inhibitor Lixiana (edoxaban), and compatriot Takeda branch Baxalta’s antihemophilic Adynovate (rurioctocog alfa pegol).
GoBroad Healthcare Group broke ground on construction of a research hospital in Beijing’s Future Science Park this week.
Analytics Snapshot