MabPharm patents CMAB020 in China, out-licenses to Sorrento for US, EU

Taizhou-based monoclonal antibody (mAb) biosimilar specialist MabPharm Ltd (02181.HK) filed a patent for its bifunctional antibody fusion protein CMAB020 at the China National Intellectual Property Administration (CNIPA). The drug is designed to prevent and treat SARS-CoV / Severe Acute Respiratory Syndrome (SARS), and SARS-CoV-2 / COVID-19. On the same day, US firm Sorrento Therapeutics Inc., (NSDQ:SRNE) entered a licensing deal with MabPharm’s wholly owned subsidiary Mabpharm HK Ltd, taking exclusive development and commercialization rights to CMAB020 in North America and the European Union (EU).

CMAB020 is an in-house developed fusion protein with two functions – coronavirus S protein-targeting monoclonal antibody (mAb) with high affinity, and truncated angiotensin-converting enzyme 2 (ACE2) protein – both of which can exert a synergistic effect and provide passive immunity for the body to prevent viral infection. CMAB020 is designed to block the life cycle of the virus, and can alleviate severe acute respiratory distress syndrome (SARDS) caused by COVID-19 and protect organs. ACE2 retains angiotensin II-converting enzyme activity, which can reduce vasoconstriction in the infected lung and increase blood perfusion, and thus is potentially effective in severe COVID-19 patients. CMAB020 also inhibits the binding of CD147 to receptors, thus reducing lung inflammation and cytokine storms.


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